A method of inhibiting 15-keto prostaglandin-.DELTA..sup.13-reductase 2 by contacting 15-keto prostaglandin-.DELTA..sup.13-reductase 2 with an aryl compound of Formula (I), (II), (III), or (IV) shown herein. Also disclosed are methods of treating peroxisome proliferators-activated receptor related diseases and lowering blood glucose levels by administering to a subject in need thereof an effective amount of such an aryl compound.