HIV replication inhibitors of formula (I) N-oxides, a pharmaceutically
acceptable addition salts, a quaternary amines or a stereoisomeric forms
thereof, wherein -a.sup.1=a.sup.2-a.sup.3=a.sup.4- is
--CH.dbd.CH--CH.dbd.CH--, --N.dbd.CH--CH.dbd.CH--,
--N.dbd.CH--N.dbd.CH--, --N.dbd.CH--CH.dbd.N--, --N.dbd.N--CH.dbd.CH--;
-b.sup.1=b.sup.2-b.sup.3=b.sup.4- is --CH.dbd.CH--CH.dbd.CH--,
--N.dbd.CH--CH.dbd.CH--, --N.dbd.CH--N.dbd.CH--, --N.dbd.CH--CH.dbd.N--,
--N.dbd.N--CH.dbd.CH--; R.sup.1 is hydrogen; aryl; formyl;
C.sub.1-6alkylcarbonyl; optionally substituted C.sub.1-6alkyl;
C.sub.1-6alkyloxycarbonyl; R.sup.2 is OH; halo; optionally substituted
C.sub.1-6alkyl, C.sub.2-6alkenyl or C.sub.2-6alkynyl; substituted
carbonyl; carboxyl; CN; nitro; amino; substituted amino; polyhalomethyl;
polyhalomethylthio; --S(.dbd.O)rR.sup.6; C(.dbd.NH)R.sup.6; R.sup.2a is
CN; amino; substituted amino; optionally substituted C.sub.1-6alkyl;
halo; optionally substituted C.sub.2-6alkyloxy; substituted carbonyl;
--CH.dbd.N--NH--C(.dbd.O)--R.sup.16; optionally substituted
C.sub.1-6alkyloxy C.sub.1-6alkyl; substituted C.sub.2-6alkenyl or
C.sub.2-6alkynyl; --C(.dbd.N--O--R.sup.8)--C.sub.1-4alkyl; R.sup.7 or
--X.sub.3--R.sup.7; X.sub.1 is --NR.sup.1--, --O--, --C(.dbd.O)--,
CH.sub.2, --CHOH--, --S--, --S(.dbd.O).sub.r--; R.sup.3 is CN; amino;
C.sub.1-6alkyl; halo; optionally substituted C.sub.1-6alkyloxy;
substituted carbonyl; --CH.dbd.N--NH--C(.dbd.O)--R.sup.16; substituted
C.sub.1-6alkyl; optionally substituted C.sub.1-6alkyloxy C.sub.1-6alkyl;
substituted C.sub.2-6alkenyl or C.sub.2-6alkynyl;
--C(.dbd.N--O--R.sup.8)--C.sub.1-4alkyl; R.sup.7; --X.sub.3--R.sup.7;
R.sup.4 is halo; OH; optionally substituted C.sub.1-6alkyl,
C.sub.2-6alkenyl or C.sub.2-6alkynyl; C.sub.3-7cycloalkyl;
C.sub.1-6alkyloxy; CN; nitro; polyhalo C.sub.1-6alkyl; polyhalo
C.sub.1-6alkyloxy; substituted carbonyl; formyl; amino; mono- or
di(C.sub.1-4alkyl)amino or R.sup.7; R.sup.5 is --Y--C.sub.qH2.sub.q-L or
--C.sub.qH.sub.2q--Y--C.sub.rH.sub.2r-L; L is aryl or Het; processes for
the preparation of these compounds, pharmaceutical compositions
comprising these compounds as active ingredient and the use of these
compounds for the prevention or the treatment of HIV infection.
