The present invention provides multi-antigenic constructs comprising one or more carbohydrate antigens having the formula: ##STR00001## ##STR00002## wherein R.sup.1, R.sup.2A, R.sup.2B, R.sup.3, R.sup.4, W.sup.1, W.sup.2 and W.sup.3 are as defined herein; and additionally provides compositions thereof, and methods for their use in the treatment and/or prevention of HIV infection, and methods for inducing HIV-specific antibodies in a subject, comprising administering to a subject in need thereof, an effective amount of any of the inventive compounds as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a gp120 glycan or glycopeptide of the invention.