Systems and methods for managing pestware are described. One system includes a pestware shield configured to detect pestware activity on a protected computer; a heuristics engine configured to identify repeat pestware activity; a drive scan module configured to scan files stored on the storage device and to identify pestware in the scanned files; a program memory scan module configured to scan programs running in the program memory of the protected computer and to identify pestware in the scanned programs; a registry scan module configured to identify any attempts to change data in the registry file; and a quarantine module configured to quarantine the pestware identified by either the drive scan module or the program memory module.