Compressors are provided which include a motor having a drive shaft; a compression chamber, having an inlet and an outlet; a diaphragm, disposed within the compression chamber such that when the diaphragm is deflected back and forth between a first position and a second position air is drawn in through the inlet and forced out through the outlet; a crankshaft, operatively connected to the drive shaft; a shuttle, configured to be displaced transversely by rotational movement of the crankshaft, and positioned to deflect the diaphragm by its transverse movement; and a guide configured to inhibit non-transverse motion of the shuttle. In some implementations, the compressor occupies a total volume of less than about 15 cubic inches.