Compounds having the formula Ia or Ib wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication. ##STR00001##

 
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< Methods of treating viral disorders

> 1,1-dioxo-1H-1.LAMBDA..sup.6-benzo[d]isothiazol-3-yl)-4-hydroxy-1,5-dihydr- o-pyrrol-2-one inhibitors of HCV polymerase

> Hepatitis C virus inhibitors
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