The present invention concerns methods for treating or preventing
neurological disorders characterized by dysfunction of nicotinic
acetylcholine receptors by administering
2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH), or a
pharmaceutically acceptable salt thereof, to the patient. In another
aspect, the present invention pertains to pharmaceutical compositions
containing TMPH, or a pharmaceutically acceptable salt thereof, and a
pharmaceutically acceptable carrier. In another aspect, the present
invention pertains to methods for selectively inhibiting nicotinic
acetylcholine receptors that lack an .alpha.5, .alpha.6, or .beta.3
subunit by contacting an effective amount of TMPH, or a pharmaceutically
acceptable salt thereof, to the receptor. The method for selectively
inhibiting nicotinic acethylcholine receptors that lack an .alpha.5
subunit can be carried out in vivo or in vitro.