The present invention intends to provide an IL-6R.cndot.IL-6 fusion
protein and the like in which IL-6R and IL-6 are directly linked without
a linker.The IL-6 receptor.cndot.IL-6 fusion protein of the present
invention has a structure in which one amino acid residue constituting
IL-6 receptor and one amino acid residue constituting IL-6 are directly
bonded.