Disclosed herein is the creation and utilization of automated diagnostic agents that are used by service engineers to diagnose faults, errors and other events or conditions within a grid-based computing system, and provide a derived list of suspect root causes for the events. Related computerized processes and network architectures and systems supporting such agents are also disclosed. The automated diagnostic agents utilize software driven rules engines that operate on facts or data, such as telemetry and event information and data in particular, according to a set of rules. The rules engine utilize a neural network analysis environment to predict in accordance with the rules, facts and data found in the grid-based system to make probabilistic determinations about the grid. Particular memory allocations, diagnostic process and subprocess interactions, and rule constructs are disclosed.