Systems and methods for wireless transmission of uncompressed HDTV signals are disclosed. In one embodiment, a method for communicating an uncompressed HDTV signal over a wireless RF link includes providing a clock signal synchronized to the uncompressed HDTV signal; providing a stream of regenerated data from the uncompressed HDTV signal, the clock signal being synchronized to the stream of regenerated data; demultiplexing the stream of regenerated data using the clock signal into an I data stream and a Q data stream; modulating a carrier with the I data stream and the Q data stream; and transmitting the modulated carrier over the wireless RF link. The synchronized clock signal may be provided using a clock and data recovery (CDR) component.