A compound of formula (I) ##STR00001## wherein: R is a group selected from: ##STR00002## A-B is a bivalent radical of formula (v), (vi) or (vii) --CH.dbd.C(R.sub.11)-- (v) --C(R.sub.10).dbd.CH-- or (vi) --C(R.sub.12)(R.sub.10)--C(R.sub.11)(R.sub.13)-- (viii) and all other variables are as defined herein or a pharmaceutically acceptable salt or solvate thereof, process for their preparation and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.