The present invention relates to isolated proteases of the RP-II type and
variants of RP-II proteases exhibiting improved properties in comparison
to the parent RP-II protease, DNA constructs and vectors coding for the
expression of said proteases and variants, host cells capable of
expressing the proteases and variants from the DNA constructs, as well as
a method of producing them by cultivating said host cells. The proteases
may advantageously be used as constituents in detergent compositions and
additives, optionally in combination with other enzymes such as
proteases, lipases, cellulases, amylases, peroxidases or oxidases.