Topical compositions having as the active ingredient a hydrophilic
material, such as a polyalkylene oxide homopolymer or copolymer, and
methods of use, have been developed for the amelioration or prevention of
pain or the sequelae of pain. The composition may be in the form of a
cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion.
In the preferred embodiment, the formulation is a gel. The composition
may contain a penetration enhancer, most preferably one with membrane
disruptive properties. In one embodiment, the compositions are
incorporated onto or into disposables such as hemorrhoid wipes, gauze,
sponge, bandages, and wraps; mouth guards, dental trays; needles or
catheters; adult diapers; gloves, socks or wrist bands, for ease of
application. The composition is applied topically to a site at or
adjacent to a painful region. The composition is reapplied as necessary.
Pain relief is typically obtained within minutes and lasts for periods of
variable duration ranging from minutes to several hours and even, in some
cases, days. The composition is variably effective to treat visceral,
somatic and neuropathic pain both acute and chronic as well as muscle
pain and stiffness and joint pain and stiffness.