A method is provided to identify a modulator of .beta.Klotho-dependant glucose transporter-1 (GLUT-1) upregulation that specifically modulates interaction of .beta.Klotho and an FGFR.

 
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> Treatment for diabetes and obesity as well as method of screening compounds useful for such treatments

> Glucagon-like peptide-1 analogs with long duration of action
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