The present invention provides a complex of the transcription coupling factor of any of ARNT 1 to 3 and the transcription regulatory factor comprising any of the amino acid sequence from the amino acid sequence group comprising for example the amino acid sequences represented by SEQ ID Nos.1 to 3, which is a transcription activating complex having an ability of binding to a DNA region (5'-ACGTG-3', SEQ ID No.16) to which a transcription inhibiting complex of the transcription coupling factor and a Sim2 as a transcription regulatory factor can be bound and having an ability of promoting the transcription of a gene located downstream of the DNA region.