Described herein are .DELTA..sup.9-THC prodrugs, methods of making
.DELTA..sup.9-THC prodrugs, formulations comprising .DELTA..sup.9-THC
prodrugs and methods of using .DELTA..sup.9-THC. One embodiment described
herein relates to the transdermal administration of a .DELTA..sup.9-THC
prodrug for treating and preventing diseases and/or disorders.