A mobile communication system, a neighboring cell interference suppression method and a base station in the mobile communication are disclosed. When a NodeB establishes a non-serving radio link for a UE, only a control plane connection is established, and contribution of the UE to uplink load in a cell is estimated by means of an established uplink channel so that contribution of UEs in neighboring cells to the uplink load becomes predictable, and the transmit power of the UE can be controlled by means of an established downlink channel based on the estimation result, and thereby interference from the neighboring cells to which the overlap area belongs can be suppressed effectively, and the system stability and accuracy in fast dispatching by the NodeB can be improved. If the non-serving radio link becomes a serving radio link during the handover, a channel for carrying data is added to the radio link.