A method of matching candidates with a user based upon, in part, on genetic factors including the following steps. First, a database is maintained including one or more of candidates having personal profiles. Next, a personal profile of a user is compared with the personal profiles of the candidates in the database for purposes of social compatibility. A set of candidates is generated which are socially compatible with the user. The personal profile of the user is then compared with each of the personal profiles of the generated set of candidates. The risk of the user producing offspring having a disease with each of the candidates within the generated set is determined. Finally, a user is presented with the set of candidates along with the determination of the risk of the user and selected candidate producing offspring having a disease.