An MRI process and system image a volume of a sample in a magnetic field established by a biasing field magnet and an array of gradient magnet fields using a pulse sequence to obtain a response that is decoded into an image or images. A set of successive images is collected while the contrast associated with lesions and tumors is enhanced with a contrast agent. A non-spoiled reference image is acquired before the application of the contrast agent. The reference image is non-spoiled in that the pulse sequence for collecting a portion of the volume image is not randomized in phase in a manner that would reset the phase effects of a previous pulse sequence. At least one other one of the successive images collected using phase spoiling pulse sequences. The non-spoiled image data is registered with and subtracted from the successive images to enhance the appearance of selected compositions in the output image, such as the contrast agent and/or water to highlight lesions and cysts, or silicone from an implant, etc., which can be highlighted by color coding.