Methods and systems for allowing multiple devices to share the same serial lines (e.g., SDIO, SEN and SCLK) are provided. Such devices can be located, e.g., on an optical pick-up unit. Each device includes a serial interface, a device enable number (DEN) that differs from the DEN of each other device, and a plurality of registers, with at least one register being designated a device select register (DSR). The DSRs of the plurality of devices share a common address. The plurality of serial interfaces are collectively enabled and collectively disabled (e.g., via the SEN line). However, only one of the plurality of serial interfaces can be selected at one time, with the remaining of the plurality of serial interfaces being deselected. The serial interface of a device is selected when the DEN of the device is the same as the content of the DSR of the device, and deselected when the DEN of the device is not the same as the content of the DSR of the device.