An apparatus for nuclear magnetic resonance measurement includes a measurement portion having a magnet for applying a magnetic field to a sample, a bore within the magnet, a nuclear magnetic resonance probe disposed in the bore, and a container for retaining the sample therein; a mixing filter portion for mixing a small molecule solution with a sample solution; a separating filter portion; a small molecule concentration controlling portion; a transmitter/receiver system; a unit for carrying out circulation solution transfer; a unit for injecting the small molecule solution; a unit for controlling the small molecule concentration; a unit for injecting the sample solution; a unit for holding the sample solution in the measurement portion; a unit for discharging the sample solution; and a unit for carrying out nuclear magnetic resonance measurement of the sample solution.