Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines,
pyrazolonaphthyridin-4-amines, and
6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions
containing the compounds, intermediates, methods of making, and methods
of use of these compounds as immunomodulators, for inducing or inhibiting
cytokine biosynthesis in animals and in the treatment of diseases
including viral and neoplastic diseases, are disclosed.