Aspects of a method and system for multi-radio coexistence and a collaborative interface may include exchanging information between a plurality of radio transceivers integrated within a single device to enable coexistence, and coordinating sharing of transmit and receive resources between the plurality of radio transceivers by controlling access to the transmit and receive resources, where any one of the plurality of radio transceivers may be enabled to be selected to control the access based on the exchanged information. Selecting one of the radio transceivers for the controlling of the access band may be based on processing capability or priority of communication. The resources may comprise frequency bands, time slots, and antenna access. The information may be exchanged via a serial bus between the plurality of radio transceivers, where the serial bus may conform to an I2C (I-square-C) multi-master serial bus. Each of the radio transceivers may conform to one or more radio frequency technology.