The present invention provides a composition comprising Rehmanniae radix, Paeonia suffruticosa, Saposhnikovia divaricata, Schizonepeta multifida, Saphora flavescens, Paeonia lactiflora, Dictamnus dasycarpus, Mentha arvensis, Rheum palmatum, Xanthium sibiricum, Campsis grandiflora and Glycyrrhizae radix for treating or prophylaxis of acne and inflammation related to skin disorders.