Materials and methods for treating fibrosis in a mammal are disclosed. The
methods comprise administering to a mammal a composition comprising a
therapeutically effective amount of a zvegf3 antagonist in combination
with a pharmaceutically acceptable delivery vehicle. Zvegf3 antagonists
include anti-zvegf3 antibodies, mitogenically inactive receptor-binding
zvegf3 variant polypeptides, and inhibitory polynucleotides. Within one
embodiment of the invention the fibrosis is liver fibrosis.