Repetitive synchronization in program code is optimized through lock coarsening that is performed subject to a number of constraints. Using a forward pass over the program code followed by a backward pass, region extent bits may be determined that identify the points in the program where object locking can be coarsened. The program code may then be modified to realize coarsened locking regions determined based on the region extent bits. Alternatively, previously determined value numbers may provide much of the information collected by the two passes. In such a case, a single pass over the program code may locate features that limit lock coarsening opportunities. A set of synchronization operations that can be removed may then be determined and used when modifying the program code to coarsen locking regions.