The present invention is directed to compound of formula (A): ##STR00001## wherein R.sub.1 is selected from (a) alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heteroaryl, or (b) CN and --C(NR.sub.10R.sub.11).dbd.N--R.sub.12, R.sub.2 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl, R.sub.3-R.sub.12 are as described within the specification, and A is O, NR.sub.9 or S, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof, provided that R.sub.1 is not alkyl when R.sub.2 is pyridine, provided that at least one of R.sub.3-R.sub.8 is not H or F when A is O, R.sub.1 is (b) and R.sub.2 is a phenyl ring, a phenyl ring substituted at the para position with halo, --CN, --OCH.sub.3, --CF.sub.3 or --CO.sub.2CH.sub.3, a quinoline or an ethylene substituted with a phenyl ring or a 3,4-methylenedioxyphenyl moiety, provided that R.sub.4 is not methyl when R.sub.3 and R.sub.5-R.sub.8 are H, A is O, R.sub.1 is (b) and R.sub.2 is 4-chlorophenyl, and provided that R.sub.6 is not Cl when R.sub.3-R.sub.5 and R.sub.7-R.sub.8 are H, R.sub.1 is CN and R.sub.2 is phenyl. This invention is also directed to methods of using the same for treating HIV infections, or AIDS, or preventing replication.