A radio frequency transmitter includes a baseband transmit processing module, a mixing module, a power amplifier, a transmit power sense module, and a transmit power control module. The baseband transmit processing module is operably coupled to encode outbound data into outbound baseband signals in accordance with one of a plurality of encoding protocols. The mixing module is operably coupled to convert the outbound baseband signals into outbound radio frequency signals. The power amplifier is operably coupled to amplify the outbound RF signals prior to transmission to produce amplified outbound RF signals. The transmit power sense module is operably coupled to sense the amplified outbound RF signals to provide a transmit signal strength indication (TSSI). The transmit power control module is operably coupled to adjust gain of the baseband transmit processing module, the mixing module, and/or the power amplifier based on the TSSI and the particular encoding protocol used to produce the baseband signals.