Peptides representing sequences from region 45-74 of the human CD38
leukocyte surface antigen (SEQ ID NO:1) are provided which may be used to
inhibit or prevent transmission or replication of the HIV virus. The
peptides have from 13 to 30 amino acids and include the amino acid
sequence GPGTTK (SEQ ID NO:18) for topical application to inhibit or
prevent transmission of the HIV virus.