Compounds and compositions of Formula I are described, useful as
anti-proliferative agents, and in particular anti-HPV, ##STR00001##
wherein: Y.sup.1A and Y.sup.1B are independently Y.sup.1; R.sup.X1 and
R.sup.X2 are independently R.sup.X; Y.sup.1 is .dbd.O, --O(R.sup.X),
.dbd.S, --N(R.sup.X), --N(O)(R.sup.X), --N(OR.sup.X), --N(O)(OR.sup.X),
or --N(N(R.sup.X) (R.sup.X)); R.sup.X is independently R.sup.1, R.sup.2,
R.sup.4, W.sup.3, or a protecting group; R.sup.1 is independently --H or
alkyl of 1 to 18 carbon atoms; R.sup.2 is independently R.sup.3 or
R.sup.4 wherein each R.sup.4 is independently substituted with 0 to 3
R.sup.3 groups or taken together at a carbon atom, two R.sup.2 groups
form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3
R.sup.3 groups; R.sup.3 is R.sup.3a, R.sup.3b, R.sup.3c or R.sup.3d,
provided that when R.sup.3 is bound to a heteroatom, then R.sup.3 is
R.sup.3c or R.sup.3d; R.sup.3a is --H, --F, --Cl, --Br, --I, --CF.sub.3,
--CN, N.sub.3, --NO.sub.2, or --OR.sup.4; R.sup.3b is .dbd.O,
--O(R.sup.4), .dbd.S, --N(R.sup.4), --N(O)(R.sup.4), --N(OR.sup.4),
--N(O)(OR.sup.4), or --N(N(R.sup.4) (R.sup.4)); R.sup.3c is --R.sup.4,
--N(R.sup.4)(R.sup.4), --SR.sup.4, --S(O)R.sup.4, --S(O).sub.2R.sup.4,
--S(O)(OR.sup.4), --S(O).sub.2(OR.sup.4), --OC(R.sup.3b)R.sup.4,
--OC(R.sup.3b)OR.sup.4, --OC(R.sup.3b)(N(R.sup.4)(R.sup.4)),
--SC(R.sup.3b)R.sup.4, --SC(R.sup.3b)OR.sup.4,
SC(R.sup.3b)(N(R.sup.4)(R.sup.4)), --N(R.sup.4)C(R.sup.3b)R.sup.4,
--N(R.sup.4)C(R.sup.3b)OR.sup.4,
N(R.sup.4)C(R.sup.3b)(N(R.sup.4)(R.sup.4)), W.sup.3 or --R.sup.5W.sup.3;
R.sup.3d is --C(R.sup.3b)R.sup.4, --C(R.sup.3b)OR.sup.4,
--C(R.sup.3b)W.sup.3, --C(R.sup.3b)OW.sup.3 or
--C(R.sup.3b)(N(R.sup.4)(R.sup.4)); R.sup.4 is --H, or an alkyl of 1 to
18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18
carbon atoms; R.sup.5 is alkylene of 1 to 18 carbon atoms, alkenylene of
2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W.sup.3 is
W.sup.4 or W.sup.5; W.sup.4 is R.sup.6, --C(R.sup.3b)R.sup.6,
--C(R.sup.3b)W.sup.5, --SO.sub.M2R.sup.6, or --SO.sub.M2W.sup.5, wherein
R.sup.6 is R.sup.4 wherein each R.sup.4 is substituted with 0 to 3
R.sup.3 groups; W.sup.5 is carbocycle or heterocycle wherein W.sup.5 is
independently substituted with 0 to 3 R.sup.2 groups; and M2 is 0, 1 or
2; and pharmaceutically acceptable salts thereof.
