An in-vivo imaging device including a ballast that may for example orient such device in a known orientation relative to the gravitational force on such ballast. Such imaging device may, for example, assume a known orientation when it is free to move, and may capture images from such known orientation. The device may include one or more imagers, which may be oriented at different angles or points of view (e.g., forward and transverse). A method of use may include moving a patient so that the device inside the patient images different fields of view.