Methods and apparatuses for configuring antennae of radio frequency identification reader systems. In one aspect of an embodiment, a radio frequency identification (RFID) reader system, includes: a receiver; a radio frequency (RF) source for signal transmission; and a switch matrix coupled with the receiver and the radio frequency sources to selectively couple the receiver and the radio frequency source to a plurality of non-collocated antennae. When in a first mode, the switch matrix connects the radio frequency source to a first one of the antennae for signal transmission and the receiver to a second one of the antennae for signal reception; and when in a second mode, the switch matrix connects the first one of the antennae for signal reception and, in one example, the second one or another one of the antennae to the RF source for signal transmission.