Compounds of formula (I), salts and solvates thereof are provided:
##STR00001##
wherein Ar is selected from phenyl, pyridyl, furanyl and thienyl, each
optionally substituted with one or more groups Y; and each Y group is
independently selected from the group consisting of: halo,
C.sub.1-4alkyl, haloC.sub.1-4alkyl, C.sub.1-4alkoxy, cyano,
C(O)C.sub.1-4alkyl, NHSO.sub.2C.sub.1-4alkyl, NMeSO.sub.2C.sub.1-4alkyl,
NHCOC.sub.1-4alkyl, NMeCOC.sub.1-4alkyl, SOC.sub.1-4alkyl,
SO.sub.2C.sub.1-4alkyl, and CO.sub.2C.sub.1-4alkyl, or two Y groups
together form a cyclic group --O(CH.sub.2)O--. Processes for preparation,
and uses thereof in the treatment of a disease or condition mediated by a
reduction or imbalance in glutamate receptor function, such as
schizophrenia or cognition impairment, are also disclosed.