A method in which one of a high-side mix mode and a low-side mix mode is selected in response to an interference characteristic of a desired channel of a radio frequency (RF) input signal is disclosed. In the high-side mix mode, a direct digital frequency synthesizer (130) is initialized to output a digital local oscillator signal at a first frequency suitable for performing a high-side mix of the desired channel to an intermediate frequency (IF). In the low-side mix mode, the direct digital frequency synthesizer (130) is initialized to output the digital local oscillator signal at a second frequency suitable for performing a low-side mix of the desired channel to said IF. The RF input signal is mixed with the digital local oscillator signal to provide an IF output signal at the IF.