A compound having GSK-3 inhibitory activity. ##STR00001## A.sup.1 and A.sup.3 are a single bond, an aliphatic hydrocarbon group; A.sup.2 and A.sup.4 are a single bond, CO, COO, CONR, O, OCO, NR, NRCO, NRCOO, etc.; G.sup.1 is a single bond, an aliphatic hydrocarbon, aromatic hydrocarbon, heterocyclic; G.sup.2 is H, an aliphatic hydrocarbon, an alicyclic hydrocarbon, an aromatic hydrocarbon, heterocyclic; A.sup.5 is a single bond, NR; R.sup.2 is H, halogen, an aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; A.sup.6 is a single bond, NR, CO, NRCO, NRCONR, CONR, COO, O, etc.; R.sup.3 is H, halogen, nitro, saturated aliphatic hydrocarbon, alicyclic hydrocarbon, aromatic hydrocarbon, heterocyclic; and R.sup.3 may be a trimethylsilyl, formyl, acyl, carboxyl, alkoxylcarbonyl, carbamoyl, alkylcarbamoyl, or cyano group when A.sup.6 is CR.dbd.CR or C.ident.C, wherein R is H or an lower aliphatic hydrocarbon group.