An endoprosthesis for orthopaedic applications comprising a prosthesis body suitable for interfacing between a first and a second bone at a first and a second wall respectively. The prosthesis body, at least one of said walls, comprises a fixing interface suitable for favouring the osteo-integration with an associable bone, which is spaced from one of the walls of the prosthesis body by a plurality of spacer elements for forming a meatus between the interface and the wall, said meatus determining cavities and undercuts suitable for seating growing bony tissue. The fixing interface comprises a reticular structure having a plurality of meshes integrally interconnected to each other and suitable for favouring the osteo-integration.