Agents useful for the treatment of various metabolic disorders, such as
insulin resistance syndrome, diabetes, polycystic ovary syndrome,
hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis
and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; q is
0 or 1; t is 0 or 1; R.sup.1 is alkyl having from 1 to 3 carbon atoms;
R.sup.2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or
alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or
substituted by 1 or 2 groups selected from: halo, alkyl having 1 or 2
carbon atoms, perfluoromethyl, hydroxy, alkoxy having 1 or 2 carbon
atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon
atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons
are independently mono-substituted by methyl or ethyl; or a 5 or 6
membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from
N, S and O and the heteroaromatic ring is covalently bound to the
remainder of the compound of formula (I) by a ring carbon. Alternatively,
the agent can be a pharmaceutically acceptable salt of the compound of
formula (I).
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