The present invention relates to the crystalline base of the well known
antidepressant drug escitalopram,
S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-f-
urancarbonitrile, formulations of said base, a process for the preparation
of purified salts of escitalopram, such as the oxalate, using the base,
the salts obtained by said process and formulations containing such
salts, and a process for the preparation of purified escitalopram free
base or salts of escitalopram, such as the oxalate, using the
hydrobromide, the salts obtained by said process and formulations
containing such salts. Finally the present invention relates to an
orodispersible tablet having a hardness of at least 22 N and an
oral-disintegration time of less than 120 s and comprising an active
pharmaceutical ingredient adsorbed onto a water soluble filler wherein
the active pharmaceutical ingredient has a melting point in the range of
40-100.degree. C., as well as a method for making such an orodispersible
tablet.