Metadherin, a protein that controls metastasis, and variants of metadherin
are described. DNA sequences encoding the same and methods of production
are described. Therapies involving the application of metadherin, binding
agents that bind to metadherin, such as antibodies, and expression
modulating agents, such as siRNA, are described. The use of metadherin or
metadherin variants for delivering desired substances to particular lung
tissue is described. A method of diagnosing metastatic cells based on the
presence of metadherin is described.