A composition derived from six plant materials: ((i) Herba epimedii .quadrature..quadrature..quadrature. (Yin Yang Huo) (ii) Fructus Psoraleae (Psoralea coryfolia) .quadrature..quadrature..quadrature. (Bu Gu Zhi) (iii) Radix Rehmanniae preparatae (Rehmannia glutinosa) .quadrature..quadrature..quadrature. (Shu Di) (iv) Cortex Eucommiae .quadrature..quadrature. (Du Zhong) (v) Fructus Cnidii .quadrature..quadrature..quadrature. (She Chuang Zhi) (vi) Radix Astragali (Astragalus Membranaceus) .quadrature..quadrature. (Huang Qi)) is useful in treating conditions linked to the activity of osteoblasts and/or osteoclasts, such as osteoporosis and other conditions relating to bone mass or the menopause; obesity; glucose intolerance; and diabetes.