A system for autonomous monitoring of administration of prescribed items for patients may include a plurality of wireless locator tags each having an indicator coupled thereto, an indoor positioning system, a database, a processor, and a radio transceiver. A method for autonomous monitoring of administration of prescribed items for patients may include detecting a contemporaneous collocation of a prescribed item and a patient, verifying that the identity of the prescribed item is equivalent to a prescribed item recorded in a physician's order for the patient, determining if the prescribed item is supplied in a correct dose and at a correct time, recording the identities of staff members in contemporaneous collocation to the patient, and commanding a locator tag coupled to a container holding the prescribed item to annunciate either an error condition if the prescribed item, dosage, or time of administration is not consistent with the physician's order, or a no error condition if the prescribed item, dosage, and time of administration are consistent with the physician's order.