A communication system is provided in which a client device can communicate with a server via any one of plural communication networks, such as a WWAN, a WLAN, a wired LAN, a personal area network (e.g., Bluetooth), and any other networking architecture. More specifically, the communication client comprises a connection manager that is adapted to determine availability of each the plural communication networks to communicate data between the client and the server, select one of the communication networks from the available ones of the plural communication networks in accordance with predetermined preferences, and establish a connection with the selected one of the communication networks. The client may further comprise a client application. The connection manager provides a notification message to the client application upon establishment of the communication link. The client application then communicates data to and from the server via the selected one of the communication networks. In an alternative embodiment of the invention, the communication system further includes an intelligent queuing system, comprising a client-side queue on the communication client and a server-side queue on the server. The connection manager is further adapted to determine cost associated with communicating the data on available ones of the plural communication networks and provide that information to the client-side queue. The client-side queue determines whether to communicate the data via the selected one of the communication networks based in part on the determined cost.