An exemplary system for measuring operational life of a computer mouse is disclosed. The system includes a computer (10), a servo controller (14), an X servo axis (12), a Y servo axis (13), and a measurement platform (16). The computer includes a file module (20), a setting module (21), and a performing module (22). The file module is configured for creating a new file for the computer mouse. The setting module is configured for setting running tasks for the computer mouse. The performing module is configured for signaling the computer to send an instruction to the servo controller, making the servo controller process the instruction and send a control signal to the X servo axis and the Y servo axis respectively, and making the X servo axis and the Y servo axis drive the computer mouse to move according to the running tasks. A related method is also disclosed.