A thermoplastic resin sheet is provided which has good penetration resistance over a range from low to high temperature region and can be used as an intermediate film of a laminated glass.The thermoplastic resin sheet has such a layered structure that a first polyvinyl acetal resin layer (A) is provided on each side of a second polyvinyl acetal resin layer (B). The first polyvinyl acetal resin layer (A) is comprised mainly of an acetalized product of polyvinyl alcohol with aldehyde (a) having 4-6 carbon atoms. The second polyvinyl acetal resin layer (B) is comprised mainly of a coacetalized product of polyvinyl alcohol with aldehyde (a) having 4-6 carbon atoms and aldehyde (b) having 1-3 carbon atoms. A polymer unit (X) derived from the aldehyde (a) and a polymer unit (Y) derived from the aldehyde (b), in total, account for at least 55% by mole while the first polymer unit (X) alone accounts for 0.5-80% by mole of the total of the coacetalized product.