Process for the preparation of programmed liberation compositions with
venlafaxine and the resulting product, from which the resulting product
allows a better absorption of the active principle and a drastic decrease
of the adverse effects, due to the preparation methodology. The
formulation comprises a first phase, in which the non-active cores are
elaborated as spherical micro granules, from sugar and starch. In the
second phase, it is added to them the active drug, as impalpable powder,
utilizing as binding, a povidone alcoholic solution. In the third phase,
it is applied the coating on the micro granules that contain the active
drug. At last, in the fourth phase, it is made the encapsulation of the
recoated micro granule.