Humans and other mammals are continually exposed to toxins in the environment, toxins in ingested food and water, and toxins formed in the body through metabolism or breakdown of complex material. Such toxins impair health and contribute to disease in mammals but are difficult to avoid given the conditions of modern life. The present invention provides compositions for promoting removal of toxins from a subject which include an alkalizing agent, spore-forming bacteria, clay, at least one type of humic acid and/or at least one type of fulvic acid. Methods for use of compositions for promoting removal of toxins from a subject are described.