Dermal fibroblasts permanently loose their ability to synthesize elastin,
the major component of elastic fibers, shortly after puberty. This
progressive loss of elastic fibers cannot be replaced, resulting in the
physical signs of aging. The present invention provides methods and
compositions containing the polyphenols ellagic acid and/or tannic acid
for protection against degradation of cutaneous elastic fibers by the
elastolytic enzymes. The use of ellagic acid and/or tannic acid increased
the overall deposition of elastic fibers in healthy and damaged skin
cells. The protection of both intra-tropoelastin and extra-cellular
mature elastic fibers from proteolytic enzymes by ellagic acid and tannic
acid caused an increase in the net deposition of elastic fibers.
Therefore, embodiments of the present invention provide methods and
composition for the treatment of skin and prevention and treatment of
degradation of dermal elastic fibers.