Compounds and compositions are provided for modulating the expression of
survivin. The compounds, exemplified by those acting through an RNAi
antisense mechanism of action, include double-stranded and
single-stranded constructs, as well as siRNAs, canonical siRNAs,
blunt-ended siRNAs and single-stranded antisense RNA compounds. Methods
of using these compounds for modulation of survivin expression and for
treatment of diseases associated with expression of survivin are
provided.