The invention disclosed in this application relates to a method designed
to obtain a non-human animal model for sarcoma characterised in that it
comprises: transfecting cells derived from a multipotent mesenchymal cell
line with an expression vector that contains a polynucleotide which
encodes a fusion protein selected from EWS-FLI1, EWS-ERG, EWS-ETV1,
EWS-ETV4, EWS-FEV, EWS-ATF1, EWS-WT1, EWS-NR4A3 and EWS-DDIT3; and
injecting said transfected cells in the animal that is the model subject.
Similarly, this invention relates to the animal model itself and its
applications, as well as the transfected cell line and the applications
thereof.