The invention disclosed in this application relates to a method designed to obtain a non-human animal model for sarcoma characterised in that it comprises: transfecting cells derived from a multipotent mesenchymal cell line with an expression vector that contains a polynucleotide which encodes a fusion protein selected from EWS-FLI1, EWS-ERG, EWS-ETV1, EWS-ETV4, EWS-FEV, EWS-ATF1, EWS-WT1, EWS-NR4A3 and EWS-DDIT3; and injecting said transfected cells in the animal that is the model subject. Similarly, this invention relates to the animal model itself and its applications, as well as the transfected cell line and the applications thereof.