The invention provides GLP-1 compounds coupled to two polyethylene glycol
molecule or derivative thereof, resulting in a biologically active
peptide with an extended half-life and a slower clearance when compared
to that of unPEGylated peptide. These PEGylated GLP-1 compounds and
compositions are useful in treating conditions or disorders benefited by
lowering blood glucose, decreasing food intake, decreasing gastric or
intestinal emptying, increasing beta (.beta.) cell population, or
decreasing gastric or intestinal motility.